KMID : 0366220110460040274
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Korean Journal of Hematology 2011 Volume.46 No. 4 p.274 ~ p.278
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Splenic infarction in a patient with autoimmune hemolytic anemia and protein C deficiency
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Park Min-Yong
Kim Jung-A Yi Seong-Yoon Chang Sun-Hee Um Tae-Hyun Lee Hye-Ran
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Abstract
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Splenic infarction is most commonly caused by cardiovascular thromboembolism; however, splenic infarction can also occur in hematologic diseases, including sickle cell disease, hereditary spherocytosis, chronic myeloproliferative disease, leukemia, and lymphoma. Although 10% of splenic infarction is caused by hematologic diseases, it seldom accompanies autoimmune hemolytic anemia (AIHA). We report a case of a 47-year-old woman with iron deficiency anemia who presented with pain in the left upper abdominal quadrant, and was diagnosed with AIHA and splenic infarction. Protein C activity and antigen decreased to 44.0% (60-140%) and 42.0% (65-140%), respectively. Laboratory testing confirmed no clinical cause for protein C deficiency, such as disseminated intravascular coagulation, sepsis, hepatic dysfunction, or acute respiratory distress syndrome. Protein C deficiency with splenic infarction has been reported in patients with viral infection, hereditary spherocytosis, and leukemia. This is a rare case of splenic infarction and transient protein C deficiency in a patient with AIHA.
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KEYWORD
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Autoimmune hemolytic anemia, Protein C deficiency, Splenic infarction
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